Mono.net and Mono Develop have come a long way; it's not only reasonable to run/develop .NET MVC on linux, it's damn near preferable.

Install Mono & Mono Develop

UPDATE April 13, 2014: Installing the latest Mono and Mono Develop is much easier than it was in 2013. It's as simple as following this:

• Install Mono
• Install Monodevelop
• Install Nuget

XSP4

To run your applications from Mono Develop you need to install xsp4

sudo apt-get install mono-xsp4 

Database Agnostic

Run you application on MS SQL Server, Mysql or Postgres.

• Connect to mysql through nhibernate
• Manage you db in an agile way with fluent migrator
• For Mysql don't forget to include the mysql-connector-net-6.4.3.

Just in Case

Off chance you have compile error related to "WebApplication.targets", look at my solution on this stack overflow

Beesbot.com ran on linux, nginx and mysql... before I moved it to jekyll.. and then moved to middleman. :)